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Dr. Silviu-Alin Bacanu, Virginia Commonwealth University describes how existing resources and other host genome studies can be used to prioritize genes and structural variants identified with Saphyr. He describes several studies including the genome-wide association studies on COVID-19 host genetics and the UK Biobank which has collected genomic data on more than 250,000 individuals. Although these large studies are unable to identify important large variants directly, their data can help prioritize variants detected by OGM based on whether they affect genes or pathways which these larger studies have identified as possible correlated with disease severity and outcome.