Watch the exceptional presentations, plus the Q&A panel discussions, on demand from Symposium 2023!

Detect More Variants that Matter in Cancer

The promise of personalized medicine depends on discovering critical insights into tumor biology that can uncover new therapeutic targets and biomarker signatures that inform care. Structural variants (SVs) are a hallmark of cancer, yet current cytogenetic and molecular methods fail to detect all classes and sizes of SVs, missing a significant amount of information critical to understanding cancer biology.1-16 Studies have shown that a significant portion of SVs detected by optical genome mapping (OGM) are being missed by traditional cytogenetic and next-generation sequencing (NGS) approaches.2,16,17

Leverage OGM to maximize SV detection, so you can build comprehensive genomic profiles of hematological malignancies and solid tumors, deepening your understanding of cancer biology and unlocking new precision medicine possibilities.

Maximize pathogenic and actionable findings.

Leverage OGM’s unbiased, genome-wide, and high-resolution capabilities to detect all classes of SVs, maximize pathogenic findings and increase the number of informed cases in hematological malignancies and solid tumor samples.

Discover new cancer biomarkers.

Unveil new meaningful events with OGM, from single SVs to complex events such as chromothripsis, or even genome-wide signatures such as homologous recombination deficiency.

Better characterize cancer samples.

Combine findings from OGM and NGS to uncover more pathogenic insights and generate comprehensive genomic profiles of tumor samples that deepen the understanding of underlying pathology.

Read Our Case Studies

Explore these cancer genomic case studies and learn how OGM uncovers SVs that short- and long-read sequencing can’t reliably identify.
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Applications

Hematological Malignancies

Detect chromosomal aberrations commonly found with traditional cytogenetics while revealing incremental pathogenic findings using a single, easy-to-implement OGM workflow.

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Solid Tumors

Use OGM to uncover meaningful SVs in solid tumor genomes that can’t be seen with NGS approaches.

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HRD

Use OGM and Bionano software solutions to characterize HRD in tumor samples.

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“30% of previously unsolved cases for B-ALL, which previously underwent karyotype + FISH + microarray + NGS, were solved using OGM.”

Dr. Gordana Raca
Children’s Hospital Los Angeles, CA, USA

“OGM found clinically relevant variants in breast cancer samples, which were missed by exome sequencing.”

Dr. Tuomo Mantere
University of Oulu, Finland

“The combination of OGM and a targeted NGS panel for genome profiling of myeloid cancer is more cost effective than 60x whole-genome sequencing and provides the most comprehensive genome analysis.”

Dr. Ravindra Kolhe
Augusta University, GA, USA

Discover How Bionano Solutions Benefit Clinical Cancer Research

Learn More About OGM

Read about what structural variations are and why they matter.

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See how OGM reveals structural variation in a way that’s never been done before.

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Find the latest research in our Publications Library.

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