Moving Us Forward

Agenda 

2024 Global Outlook: Serving Breakfast with the OGM Global Community 
8:00am – 9:20am 
Host: Erik Holmlin, PhD, CEO, Bionano 

Join us bright and early at 8:00 AM for an enriching start to your day with our exclusive breakfast networking event. This is a perfect opportunity to connect with fellow pioneers in the field of genome analysis and to forge valuable relationships over a delightful morning spread. 

At 9:00 AM, we are honored to present Bionano Genomics’ esteemed CEO, Erik Holmlin, who will who will share a visionary outlook on the advancements and future directions of OGM for 2024. This session promises to offer profound insights into the global OGM community’s trajectory, highlighting groundbreaking developments and strategic initiatives that Bionano is poised to lead. 

Advancing Knowledge: OGM Education Workshop 
9:20am – 10:00am 
Hosts: 

• Uli Broeckel, MD, Medical College of Wisconsin 
• Brynn Levy, MSc, FACMG, PhD, Columbia University Medical Center 
• Susan Crocker, PhD, FCCMG, Kingston Health Sciences Centre 

This OGM educational session will begin with Dr. Brynn Levy detailing the emergence of OGM followed by an overview of an international consortium’s efforts to provide a framework for implementation of OGM in a new lab. Next, Dr. Uli Broeckel will review how he is using the VIA software to compare OGM to chromosomal microarray and integrate with long read sequencing in constitutional disorders. The session will finish with Dr. Susan Crocker sharing her expertise in implementing comprehensive workflows in the analysis of hematological malignancies and constitutional diseases leveraging VIA.  

Innovating the Future of OGM: A Stratys Innovation Workshop 
10:00am – 11:25am 
Hosts: 

• Darisha Jiandani, MS, Bionano
• Zeid Hamadeh, PhD, Vancouver General Hospital
• Liz McCready, PhD, MSc, FCCMG, Hamilton Health Science Center
• Trilochan Sahoo, PhD, Bionano

The Stratys Innovation Sessions will debut the Stratys™ System live, Bionano’s latest high throughput genome analysis instrument. Darisha Jiandani, Bionano’s Director of Product Management, will showcase its high sample capacity and ultimate flexibility for the OGM workflow. Dr. Liz McCready of Hamilton Science Center will discuss work conducted in her lab and her motivations for adopting the Stratys System. Trilochan Sahoo of Bionano Labs will review their Stratys data compared to the data from the previous instrument, the Saphyr System. Concluding the session, Dr. Zeid Hamadeh from Vancouver General Hospital will share his insights from that lab’s initial installation and onboarding of Stratys, offering a comprehensive view of its impact and utility. 

 Moving Forward Fireside Chat & The Stratysphere Evolution 
11:35am-12:30pm 
Moderator: Alka Chaubey, PhD, FACMG, Bionano 
Hosts: 

• Uli Broeckel, MD, Medical College of Wisconsin
• Brynn Levy, MSc, FACMG, PhD, Columbia University Medical Center
• Susan Crocker, PhD, Kingston General Hospital
• Zeid Hamadeh, PhD, Vancouver General Hospital
• Liz McCready, PhD, MSc, FCCMG, Hamilton Health Science Center

We will conclude the product showcase with an enlightening Fireside Chat session, moderated by Bionano’s Chief Medical Officer, Dr. Alka Chaubey. This session promises a dynamic dialogue with our esteemed panelists, who presented valuable data and insights throughout the product showcase. We invite you to pose questions that will prompt a deeper exploration of the features and advancements awaiting the entire OGM workflow. Be part of this interactive discussion that not only highlights what’s on the horizon for OGM but also encourages a collaborative framework for the journey our global community is embarking on together. 

Join us for the unveiling of the newly elevated high throughput Stratys OGM system by Bionano. This session will showcase the system’s unparalleled capacity to consolidate various cytogenetic workflows, offering a unique genome-wide, high-resolution analysis of structural and numerical variants, at scale. Our first presenter will introduce OGM’s increased success rate in clinical research cases from a large multi-site study. The presentation will also include an introduction into the key features and benefits of this new platform, showcasing the seamless sample-to-answer workflow, from sample preparation to advanced bioinformatic classification, interpretation and reporting of structural variants leveraging the robust capabilities of Bionano’s VIA™ software. Our second speaker will present insights from a laboratory specializing in cytogenomic assessment for hematologic malignancies, highlighting the Stratys system’s integration and efficiency in high throughput routine cytogenetic analysis. Discover how the Stratys system is setting new benchmarks in genomic analysis, providing solutions for faster turnaround times, high throughput, and precision in detecting key structural variants across disease samples. 

Diagnosis and management of hematologic malignancies relies heavily on detection of specific genetic abnormalities that can drive oncogenesis, impact prognosis, and alter responses to therapy. In Canada, standard-of-care (SOC) cytogenetic techniques for detecting genetic abnormalities in cancer include karyotype and fluorescence in-situ hybridization (FISH), both of which yield limited resolution in uncovering complex genomic anomalies that are abundant in this context. Here, we report the results of our clinical validation of OGM  for use in diagnostic genotyping of hematological neoplasms.