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Maximize the Detection of Pathogenic Aberrations With Optical Genome Mapping

Hematological malignancies are characterized by multiple classes of chromosomal aberrations. Comprehensive detection of these aberrations is vital to properly classify samples and provide actionable information. Due to the limitations of current cytogenetic approaches, only a fraction of the samples evaluated lead to a positive aberration finding11-13. Optical genome mapping (OGM) significantly improves detection to unlock truly comprehensive chromosomal aberration profiles and maximize the number of informed cases.

Achieve, with a single assay, detection of aberrations from all classical cytogenetic technologies combined.

  • With a single workflow, find all classes of chromosomal aberrations detected by karyotyping, FISH, and chromosomal microarrays combined
  • Generate results with >99% concordance with standard cytogenomic methods as demonstrated by multiple peer-reviewed studies
  • Achieve 10,000x resolution and higher sensitivity compared to karyotyping, with a scalable digital approach

 

Find more pathogenic and actionable chromosomal abnormalities.

  • Reveal significantly more pathogenic aberrations than classical cytogenetics, with a higher-resolution, genome-wide, and unbiased method
  • Enable more pathogenic discoveries, resolve cryptic cases, and determine complex events like chromothripsis with much higher precision and resolution
  • Increase the number of informed cases, and reduce the rate of cases signed off as “normal” due to lack of findings from classical methods

Simplify and transform your lab operations.

  • Transform your lab operations by reducing complexity and number of assays required per sample
  • Implement a simpler sample-to-answer workflow that does not require cell culture and has more automated steps with simpler data analysis
  • Leverage sophisticated software solutions to visualize and call variants, annotate and interpret findings, and report results

Curated Publications

See the research global experts are publishing on OGM and hematological malignancies.
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“The combination of OGM and a targeted NGS panel for genome profiling of myeloid cancer is more cost effective than 60x whole-genome sequencing and provides the most comprehensive genome analysis.”

Dr. Ravindra Kolhe
Augusta University

“30% of previously unsolved cases for B-ALL, which previously underwent karyotype + FISH + microarray + NGS, were solved using OGM.”

Dr. Gordana Raca
Children’s Hospital Los Angeles

Data Examples

Multiple peer-reviewed studies from global experts have demonstrated the same outcomes: OGM has a high correlation to results from traditional methods across diverse types of hematological malignancies, while consistently revealing additional pathogenic findings.

When compared to traditional cytogenetic methods, OGM can uncover up to twice as many pathogenic chromosomal aberrations.

In a 2022 MD Anderson Cancer Center study, OGM detected twice the number of clinically significant chromosomal aberrations as karyotyping in 101 myelodysplastic samples.8 This figure illustrates the Circos plot view of the variants identified by karyotyping (left) versus OGM (right).

High-resolution and enhanced characterization of samples by OGM also leads to better risk analysis and stratification of samples.

 

Disease Impact of OGM Analysis
AML and MDS9 For 67% of cases, the karyotype was redefined. In some cases, this led to an adjustment in ELN risk classifications
AML and MDS10 11% of samples for which OGM findings led to change in R-IPSS or 2010/2017 ELN score
MDS8 17% of cases assessed with OGM had the IPSS-R risk reclassified from initial karyotyping

Discover How OGM Benefits Clinical Research in Cancer

Sign up to watch the AMP 2022 Bionano Corporate Workshop #1, which discusses Maximizing Detection of Pathogenic Structural Variants Across Hematological Malignancies with Optical Genome Mapping.

Watch Videos

Sign up to watch this webinar and hear from Bionano’s Dr. Alka Chaubey and Dr. Adam Smith, UHN, as they discuss how Optical Genome Mapping Meets Challenges for New Blood Cancer Classifications

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Sign up to watch this webinar and hear how OGM makes a huge impact on clinical research, as Dr. Rashmi Kanagal-Shamanna and Dr. Guillermo Garcia-Manero (MD Anderson Cancer Center) discuss OGM for Enhanced Characterization of Myelodysplastic Syndromes.

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Learn More About OGM

Read about what structural variations are and why they matter.

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See how OGM reveals structural variation in a way that has never been done before.

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Find the latest research in our Publications Library.

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